Endocrine Abstracts

Introduction: Bardet-Biedl Syndrome (BBS) is an autosomal recessive disease and one of the most common causes of syndromic obesity. An excessive weight usually appears at an early age and affects almost 90% of patients. Mutations in BBS genes have been found to disrupt the function of the cilia, leading to disturbances of transduction satiety and hunger signals in hypothalamus and increased adipogenesis in the fat tissue.Methods: We present a case series...

Background: The renin-angiotensin-aldosterone system (RAS) constitutes a key hormonal system in the physiological and pathological regulation of blood pressure. In effort to understand complex and multifunctional aspects of this system, current biochemical approaches target to characterize and define its various components with angiotensin II being in the mainstream.Objective: The aim of this study was to evaluate concentrations of angiotensin II in hype...